The ONE Super Series was inaugurated in 2018. The first ever Muay Thai and Kickboxing bouts in ONE Championship took place at ONE: Heroes of Honor on April 20, 2018. Sam-A Gaiyanghadao became the first ever ONE Championship Muay Thai World Champion. He defeated Sergio Wielzen for the inaugural ONE Flyweight Muay Thai World title at ONE: Unstoppable Dream on May 18, 2018. Below is a list of the current and all-time ONE Championship Muay Thai World champions.
|Joseph Lasiri (0)||May 20, 2022||Prajanchai PK Saenchaimuaythaigym|
|Prajanchai PK Saenchaimuaythaigym (1)||July 30, 2021||Sam-A Gaiyanghadao|
|Sam-A Gaiyanghadao (2)||February 28, 2020||Rocky Ogden|